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Article

A polymorphism at the 3'-UTR region of the aromatase gene is associated with the efficacy of the aromatase inhibitor, anastrozole, in metastatic breast carcinoma.

International journal of molecular sciences - 13 Sept 2013

Liu Lei, Bai Yu-Xian, Zhou Jian-Hua, Sun Xiu-Wei, Sui Hong, Zhang Wen-Jie, Yuan Heng-Heng, Xie Rui, Wei Xiao-Li, Zhang Ting-Ting, Huang Peng, Li Yan-Jing, Wang Jing-Xuan, Zhao Shu, Zhang Qing-Yuan

Abstract excerpt

Estrogen-related genes and the fat mass and obesity-associated (FTO) gene play a critical role in estrogen metabolism, and those polymorphisms are associated with a poor prognosis in breast cancer. However, little is known about the association between these polymorphisms and the efficacy of anastrozole. The aim was to investigate the impact of the genetic polymorphisms, CYP19A1, 17-β-HSD-1 and FTO, on the...

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Source

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Identifiers

PMID: 24065098
DOI: 10.3390/ijms140918973
PMCID: PMC3794816

Genes

FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A polymorphism at the 3'-UTR region of the aromatase gene is associated with the efficacy of the aromatase inhibitor, anastrozole, in metastatic breast carcinoma.PMID 24065098Read ↗

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