Article
Single nucleotide polymorphisms of the aromatase gene (CYP19A1), HER2/neu status, and prognosis in breast cancer patients.
Breast cancer research and treatment - 1 Nov 2008
Fasching Peter Andreas, Loehberg Christian R, Strissel Pamela L, Lux Michael P, Bani Mayada R, Schrauder Michael, Geiler Sonja, Ringleff Kerstin, Oeser Sonja, Weihbrecht Sebastian, Schulz-Wendtland Rüdiger, Hartmann Arndt, Beckmann Matthias W, Strick Reiner
Abstract excerpt
PURPOSE: Estrogen exposure is involved in both breast cancer susceptibility and the prognosis in patients with breast cancer. Aromatase is involved in the production of estrogens, and altered expression of it might be associated with the prognosis. The aim of this study was to examine the effect of single nucleotide polymorphisms (SNPs) in the aromatase gene, CYP19A1, on the prognosis, and in relation to tumor...
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