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Article

Neurospora importin α is required for normal heterochromatic formation and DNA methylation.

PLoS genetics - 1 Mar 2015

Klocko Andrew D, Rountree Michael R, Grisafi Paula L, Hays Shan M, Adhvaryu Keyur K, Selker Eric U

Abstract excerpt

Heterochromatin and associated gene silencing processes play roles in development, genome defense, and chromosome function. In many species, constitutive heterochromatin is decorated with histone H3 tri-methylated at lysine 9 (H3K9me3) and cytosine methylation. In Neurospora crassa, a five-protein complex, DCDC, catalyzes H3K9 methylation, which then directs DNA methylation. Here, we identify and characterize a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25793375
DOI: 10.1371/journal.pgen.1005083
PMCID: PMC4368784

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