Article
A genomic duplication is associated with ectopic eomesodermin expression in the embryonic chicken comb and two duplex-comb phenotypes.
PLoS genetics - 1 Mar 2015
Dorshorst Ben, Harun-Or-Rashid Mohammad, Bagherpoor Alireza Jian, Rubin Carl-Johan, Ashwell Chris, Gourichon David, Tixier-Boichard Michèle, Hallböök Finn, Andersson Leif
Abstract excerpt
Duplex-comb (D) is one of three major loci affecting comb morphology in the domestic chicken. Here we show that the two Duplex-comb alleles, V-shaped (D*V) and Buttercup (D*C), are both associated with a 20 Kb tandem duplication containing several conserved putative regulatory elements located 200 Kb upstream of the eomesodermin gene (EOMES). EOMES is a T-box transcription factor that is involved in mesoderm...
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