Article
Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens.
PLoS genetics - 1 Jun 2009
Wright Dominic, Boije Henrik, Meadows Jennifer R S, Bed'hom Bertrand, Gourichon David, Vieaud Agathe, Tixier-Boichard Michèle, Rubin Carl-Johan, Imsland Freyja, Hallböök Finn, Andersson Leif
Abstract excerpt
Pea-comb is a dominant mutation in chickens that drastically reduces the size of the comb and wattles. It is an adaptive trait in cold climates as it reduces heat loss and makes the chicken less susceptible to frost lesions. Here we report that Pea-comb is caused by a massive amplification of a duplicated sequence located near evolutionary conserved non-coding sequences in intron 1 of the gene encoding the SOX5...
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