Article
The Rose-comb mutation in chickens constitutes a structural rearrangement causing both altered comb morphology and defective sperm motility.
PLoS genetics - 1 Jun 2012
Imsland Freyja, Feng Chungang, Boije Henrik, Bed'hom Bertrand, Fillon Valérie, Dorshorst Ben, Rubin Carl-Johan, Liu Ranran, Gao Yu, Gu Xiaorong, Wang Yanqiang, Gourichon David, Zody Michael C, Zecchin William, Vieaud Agathe, Tixier-Boichard Michèle, Hu Xiaoxiang, Hallböök Finn, Li Ning, Andersson Leif
Abstract excerpt
Rose-comb, a classical monogenic trait of chickens, is characterized by a drastically altered comb morphology compared to the single-combed wild-type. Here we show that Rose-comb is caused by a 7.4 Mb inversion on chromosome 7 and that a second Rose-comb allele arose by unequal crossing over between a Rose-comb and wild-type chromosome. The comb phenotype is caused by the relocalization of the MNR2 homeodomain...
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