Novel ATP-competitive kinesin spindle protein inhibitors.

doi:10.1021/jm070435y

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Article

Novel ATP-competitive kinesin spindle protein inhibitors.

Journal of medicinal chemistry - 4 Oct 2007

Parrish Cynthia A, Adams Nicholas D, Auger Kurt R, Burgess Joelle L, Carson Jeffrey D, Chaudhari Amita M, Copeland Robert A, Diamond Melody A, Donatelli Carla A, Duffy Kevin J, Faucette Leo F, Finer Jeffrey T, Huffman William F, Hugger Erin D, Jackson Jeffrey R, Knight Steven D, Luo Lusong, Moore Michael L, Newlander Ken A, Ridgers Lance H, Sakowicz Roman, Shaw Antony N, Sung Chiu-Mei M, Sutton David, Wood Kenneth W, Zhang Shu-Yun, Zimmerman Michael N, Dhanak Dashyant

Abstract excerpt

Kinesin spindle protein (KSP), an ATPase responsible for spindle pole separation during mitosis that is present only in proliferating cells, has become a novel and attractive anticancer target with potential for reduced side effects compared to currently available therapies. We report herein the discovery of the first known ATP-competitive inhibitors of KSP, which display a unique activity profile as compared to...

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PMID: 17725339
DOI: 10.1021/jm070435y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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