Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Risk factors for gyrA and parC mutations in Pseudomonas aeruginosa.

Infection control and hospital epidemiology - 1 Apr 2015

Cluzet Valerie C, Lautenbach Ebbing, Nachamkin Irving, Cary Mark S, Fishman Neil O, Shih Natalie N C, Morales Knashawn H, Linkin Darren R

Abstract excerpt

OBJECTIVE: The major mechanism of fluoroquinolone (FQ) resistance in Pseudomonas aeruginosa (PSA) is modification of target proteins in DNA gyrase and topoisomerase IV, most commonly the gyrA and parC subunits. The objective of this study was to determine risk factors for PSA with and without gyr...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross Infection
Share to DNA Gyrase
Share to DNA Topoisomerase IV

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Levofloxacin

Share to Pseudomonas aeruginosa

Share to Pseudomonas Infections

Share to Vancomycin

Source

Open in PubMed Open full text

Identifiers

PMID: 25782892
DOI: 10.1017/ice.2014.87
PMCID: PMC9862507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25782892-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Risk factors for gyrA and parC mutations in Pseudomonas aeruginosa.PMID 25782892Read ↗

The role of Gene Mutations (gyrA, parC) in Resistance to Ciprofloxacin in Clinical Isolates of Pseudomonas AeruginosaSemantic proximity Read ↗

Mutations in the gyrA, parC, and mexR genes provide functional insights into the fluoroquinolone-resistant Pseudomonas aeruginosa isolated in VietnamSemantic proximity Read ↗

The role of gyrA and parC mutations in fluoroquinolones-resistant Pseudomonas aeruginosa isolates from Iran.Semantic proximity Read ↗

Alterations in the gyrA and parC genes in Salmonella spp. following in vitro exposure to fluoroquinolones.Semantic proximity Read ↗

Alterations of gyrA, gyrB, and parC and Activity of Efflux Pump in Fluoroquinolone-resistant Acinetobacter baumanniiSemantic proximity Read ↗

A novel parC mutation potentiating fluoroquinolone resistance in Klebsiella pneumoniae and Escherichia coli clinical isolates.Semantic proximity Read ↗

Characterization of the quinolone resistant determining regions in clinical isolates of pneumococci collected in Canada.Semantic proximity Read ↗

Type II topoisomerase mutations in ciprofloxacin-resistant strains of Pseudomonas aeruginosa.Semantic proximity Read ↗

Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa.Semantic proximity Read ↗

Evaluation of bacterial kill when modelling the bronchopulmonary pharmacokinetic profile of moxifloxacin and levofloxacin against parC-containing isolates of Streptococcus pneumoniae.Semantic proximity Read ↗

Alteration in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV in quinolone-resistant clinical isolates of Staphylococcus epidermidis.Semantic proximity Read ↗

A mutation in QRDR in the ParC subunit of topoisomerase IV was responsible for fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.