Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spectrum of MLH1 and MSH2 mutations in Chilean families with suspected Lynch syndrome.

Diseases of the colon and rectum - 1 Apr 2010

Alvarez Karin, Hurtado Claudia, Hevia Montserrat A, Wielandt Ana Maria, de la Fuente Marjorie, Church James, Carvallo Pilar, López-Köstner Francisco

Abstract excerpt

PURPOSE: Lynch syndrome is the most common inherited syndrome of colorectal cancer, caused principally by germline mutations in MLH1 and MSH2. We report our experience with genetic screening in the diagnosis of Lynch syndrome in Chile, a country previously underserved in the capacity to diagnose hereditary colorectal cancer. METHODS: Families from our Familial Colorectal Cancer Registry were selected for this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chile
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoenzyme Techniques

Share to Microsatellite Instability

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Share to Polymorphism, Single-Stranded Conformational

Share to Registries

Source

Identifiers

PMID: 20305446
DOI: 10.1007/DCR.0b013e3181d0c114

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spectrum of MLH1 and MSH2 mutations in Chilean families with suspected Lynch syndrome.PMID 20305446Read ↗

A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America.Semantic proximity Read ↗

A Previously Unrecognized Molecular Landscape of Lynch Syndrome in the Mexican PopulationSemantic proximity Read ↗

Clinical characterization and mutation spectrum in Caribbean Hispanic families with Lynch syndrome.Semantic proximity Read ↗

Clinicopathological and molecular characterization of Brazilian families at risk for Lynch syndrome.Semantic proximity Read ↗

Association between the Lynch syndrome gene MSH2 and breast cancer susceptibility in a Canadian familial cancer registry.Semantic proximity Read ↗

MLH1 and MSH2 mutations in Colombian families with hereditary nonpolyposis colorectal cancer (Lynch syndrome)--description of four novel mutations.Semantic proximity Read ↗

Hereditary nonpolyposis colorectal cancer (Lynch Syndrome) in Argentina: report from a referral hospital register.Semantic proximity Read ↗

Germline MLH1, MSH2 and MSH6 variants in Brazilian patients with colorectal cancer and clinical features suggestive of Lynch Syndrome.Semantic proximity Read ↗

A Chinese family affected by lynch syndrome caused by MLH1 mutation.Semantic proximity Read ↗

Mutation spectrum in South American Lynch syndrome familiesSemantic proximity Read ↗

Association of colonic and endometrial carcinomas in Portuguese families with hereditary nonpolyposis colorectal carcinoma significantly increases the probability of detecting a pathogenic mutation in mismatch repair genes, primarily the MSH2 gene.Semantic proximity Read ↗

[Lynch syndrome: case report and review of the literature].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.