Forecasting Multitrait Resistance Evolution under Antibiotic Stress.

Abstract excerpt

Many bacteria rely on efflux pumps to survive antibiotic stress and exposure to antibiotics often leads to mutations in pump genes or their regulators that increase pump expression. Predicting the spectrum of these mutations is important for designing effective antibiotic treatments, but the underlying regulatory networks are large and complex, making them difficult to map experimentally. To address this...

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