Article
Methionine to isothreonine conversion as a source of false discovery identifications of genetically encoded variants in proteogenomics.
Journal of proteomics - 29 Apr 2015
Chernobrovkin Alexey L, Kopylov Arthur T, Zgoda Victor G, Moysa Alexander A, Pyatnitskiy Mikhail A, Kuznetsova Ksenia G, Ilina Irina Y, Karpova Maria A, Karpov Dmitry S, Veselovsky Alexander V, Ivanov Mark V, Gorshkov Mikhail V, Archakov Alexander I, Moshkovskii Sergei A
Abstract excerpt
Searching deep proteome data for 9 NCI-60 cancer cell lines obtained earlier by Moghaddas Gholami et al. (Cell Reports, 2013) against a database from cancer genomes returned a variant tryptic peptide fragment 57-72 of molecular chaperone HSC70, in which methionine residue at 61 position is replaced by threonine, or isothreonine (homoserine), residue. However, no traces of the corresponding genetic alteration were...
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