Article
YAP is essential for tissue tension to ensure vertebrate 3D body shape.
Nature - 14 May 2015
Porazinski Sean, Wang Huijia, Asaoka Yoichi, Behrndt Martin, Miyamoto Tatsuo, Morita Hitoshi, Hata Shoji, Sasaki Takashi, Krens S F Gabriel, Osada Yumi, Asaka Satoshi, Momoi Akihiro, Linton Sarah, Miesfeld Joel B, Link Brian A, Senga Takeshi, Shimizu Nobuyoshi, Nagase Hideaki, Matsuura Shinya, Bagby Stefan, Kondoh Hisato, Nishina Hiroshi, Heisenberg Carl-Philipp, Furutani-Seiki Makoto
Abstract excerpt
Vertebrates have a unique 3D body shape in which correct tissue and organ shape and alignment are essential for function. For example, vision requires the lens to be centred in the eye cup which must in turn be correctly positioned in the head. Tissue morphogenesis depends on force generation, force transmission through the tissue, and response of tissues and extracellular matrix to force. Although a century ago...
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