Yap1 regulates motility and vertebral development and prevents kyphoscoliosis in zebrafish.

Abstract excerpt

Scoliosis affects 2-3% of people, often developing during and after adolescence, and currently has a lifetime chance of surgical intervention of ~0.1% in high income countries. Understanding of causal genetic and environmental factors is improving, with mechanical feedback interactions between the neuromuscular and skeletal systems thought to be important. While examining mechanosignalling in the zebrafish...

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