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Biasing Amacrine Subtypes in the Atoh7 Lineage through Expression of Barhl2

3 Oct 2012

Abstract excerpt

Within the developing vertebrate retina, particular subtypes of amacrine cells (ACs) tend to arise from progenitors expressing the basic helix-loop-helix (bHLH) transcription factor, Atoh7, which is necessary for the early generation of retinal ganglion cells (RGCs). All ACs require the postmitotic expression of the bHLH pancreas transcription factor Ptf1a; however, Ptf1a alone is not sufficient to give subtype...

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PMID: 23035102
DOI: 10.1523/jneurosci.2073-12.2012

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