Potential contribution of mitochondrial DNA damage associated molecular patterns in transfusion products to the development of acute respiratory distress syndrome after multiple transfusions

Abstract excerpt

BACKGROUND: Massive transfusions are accompanied by an increased incidence of a particularly aggressive and lethal form of acute lung injury (delayed transfusion-related acute lung injury) which occurs longer than 24 hours after transfusions. In light of recent reports showing that mitochondrial (mt)DNA damage-associated molecular patterns (DAMPs) are potent proinflammatory mediators, and that their abundance in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blood transfusion and management
• Share to Immune Response and Inflammation
• Share to Sepsis Diagnosis and Treatment