Synergistic Activations of<i>REG I<b><i>α</i></b></i>and<i>REG I</i><b><i>β</i></b>Promoters by IL-6 and Glucocorticoids through JAK/STAT Pathway in Human Pancreatic<b><i>β</i></b>Cells

Abstract excerpt

Reg (Regenerating gene) gene was originally isolated from rat regenerating islets and its encoding protein was revealed as an autocrine/paracrine growth factor for β cells. Rat Reg gene is activated in inflammatory conditions for β cell regeneration. In human, although five functional REG family genes (REG Iα, REG Iβ, REG III, HIP/PAP, and REG IV) were isolated, their expressions in β cells under inflammatory...

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