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Article

Production and Characterization of <i>Reg</i> Knockout Mice

1 Dec 2002

Abstract excerpt

Reg (regenerating gene) was isolated as a gene specifically expressed in regenerating islets. We have demonstrated in vitro and in vivo that the exogenous addition of rat and human Reg gene products, Reg/REG proteins, induced beta-cell replication via the Reg receptor and thereby ameliorated experimental diabetes. In the present study, we produced Reg knockout mice by homologous recombination. The Reg gene...

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Identifiers

PMID: 12475793
DOI: 10.2337/diabetes.51.2007.s478

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