Article
Reg3g overexpression promotes β cell regeneration and induces immune tolerance in nonobese-diabetic mouse model.
Journal of leukocyte biology - 1 Jun 2016
Xia Fei, Cao Hui, Du Jiao, Liu Xiulan, Liu Yang, Xiang Ming
Abstract excerpt
The regenerating islet-derived gene was first isolated in regenerated pancreas tissues, greatly contributing to β cell regeneration. It is an anti-inflammatory in response to cellular stress. This encouraged us to investigate the exact role of a novel member of Reg family, regenerating islet-derived gene γ, in type 1 diabetes of nonobese-diabetic mice. For this, Reg3g gene was overexpressed in pancreatic islets,...
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