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Article

Prevention of Reg I-induced β-cell apoptosis by IL-6/dexamethasone through activation of HGF gene regulation.

Biochimica et biophysica acta - 1 Dec 2013

Nakagawa Kei, Takasawa Shin, Nata Koji, Yamauchi Akiyo, Itaya-Hironaka Asako, Ota Hiroyo, Yoshimoto Kiyomi, Sakuramoto-Tsuchida Sumiyo, Miyaoka Tomoko, Takeda Maiko, Unno Michiaki, Okamoto Hiroshi

Abstract excerpt

Reg (regenerating gene) product, Reg protein, is induced in pancreatic β-cells and acts as autocrine/paracrine growth factor for regeneration via the cell surface Reg receptor. However, high concentrations of Reg I protein induced β-cell apoptosis. In the present study, we found that hepatocyte growth factor (HGF) attenuated the β-cell apoptosis induced by the high concentrations of Reg I protein and that the...

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Identifiers

PMID: 23954444
DOI: 10.1016/j.bbamcr.2013.08.004

Genes

HGF
STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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