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Article

FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2015

Yakkundi Anita, Bennett Rachel, Hernández-Negrete Ivette, Delalande Jean-Marie, Hanna Mary, Lyubomska Oksana, Arthur Kenneth, Short Amy, McKeen Hayley, Nelson Laura, McCrudden Cian M, McNally Ross, McClements Lana, McCarthy Helen O, Burns Alan J, Bicknell Roy, Kissenpfennig Adrien, Robson Tracy

Abstract excerpt

OBJECTIVE: The antitumor effects of FK506-binding protein like (FKBPL) and its extracellular role in angiogenesis are well characterized; however, its role in physiological/developmental angiogenesis and the effect of FKBPL ablation has not been evaluated. This is important as effects of some angiogenic proteins are dosage dependent. Here we evaluate the regulation of FKBPL secretion under angiogenic stimuli, as...

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Source

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Identifiers

PMID: 25767277
DOI: 10.1161/ATVBAHA.114.304539
PMCID: PMC4415967

Genes

FKBPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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