Article
Analysis of the estrogen receptor gene structure in human breast cancer.
Anticancer research - 1 Jan 2000
Koh E H, Ro J, Wildrick D M, Hortobagyi G N, Blick M
Abstract excerpt
We studied the structure of the human estrogen receptor (ER) gene by Southern blot analysis in 34 tumor samples and normal breast tissues or peripheral blood samples from the same patients. No rearrangement or amplification of the ER gene was seen in either ER-positive or ER-negative breast tumors. One patient showed an apparent constitutional deletion of a non-allelic ("invariant") restriction fragment in DNAs...
Topics
- Alleles
- Blotting, Southern
- Breast
- Breast Neoplasms
- DNA
- DNA, Neoplasm
- Deoxyribonucleases, Type II Site-Specific
- Genotype
- Humans
- Immunoblotting
- Nucleic Acid Hybridization
- Polymorphism, Restriction Fragment Length