Article
Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: the Generation R Study.
European journal of epidemiology - 1 Apr 2015
Medina-Gomez Carolina, Felix Janine Frédérique, Estrada Karol, Peters Marjoline Josephine, Herrera Lizbeth, Kruithof Claudia Jeanette, Duijts Liesbeth, Hofman Albert, van Duijn Cornelia Marja, Uitterlinden Andreas Gerardus, Jaddoe Vincent Wilfred Vishal, Rivadeneira Fernando
Abstract excerpt
Genome-wide association studies (GWAS) have been successful in identifying loci associated with a wide range of complex human traits and diseases. Up to now, the majority of GWAS have focused on European populations. However, the inclusion of other ethnic groups as well as admixed populations in GWAS studies is rapidly rising following the pressing need to extrapolate findings to non-European populations and to...
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