Article
Statistical perspectives for genome-wide association studies (GWAS).
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Barrett Jennifer H, Taylor John C, Iles Mark M
Abstract excerpt
In this chapter we consider some key elements in conducting a successful genome-wide association study or GWAS. The first step is to design the study well (Subheading 3.1), paying particular attention to case and control selection and achieving adequate sample size to deal with the large burden of multiple testing. Second, we focus on the crucial step of applying stringent quality control (Subheading 3.2) to...
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