Article
Correction of population stratification in large multi-ethnic association studies.
PloS one - 2 Jan 2008
Serre David, Montpetit Alexandre, Paré Guillaume, Engert James C, Yusuf Salim, Keavney Bernard, Hudson Thomas J, Anand Sonia
Abstract excerpt
BACKGROUND: The vast majority of genetic risk factors for complex diseases have, taken individually, a small effect on the end phenotype. Population-based association studies therefore need very large sample sizes to detect significant differences between affected and non-affected individuals. In...
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