Article
A genome-wide screen identifies PAPP-AA-mediated IGFR signaling as a novel regulator of habituation learning.
Neuron - 18 Mar 2015
Wolman Marc A, Jain Roshan A, Marsden Kurt C, Bell Hannah, Skinner Julianne, Hayer Katharina E, Hogenesch John B, Granato Michael
Abstract excerpt
Habituation represents a fundamental form of learning, yet the underlying molecular genetic mechanisms are not well defined. Here we report on a genome-wide genetic screen, coupled with whole-genome sequencing, that identified 14 zebrafish startle habituation mutants including mutants of the vert...
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