Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma.

doi:10.1093/neuonc/nov015

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Article

Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma.

Neuro-oncology - 1 Oct 2015

Ramkissoon Shakti H, Bi Wenya Linda, Schumacher Steven E, Ramkissoon Lori A, Haidar Sam, Knoff David, Dubuc Adrian, Brown Loreal, Burns Margot, Cryan Jane B, Abedalthagafi Malak, Kang Yun Jee, Schultz Nikolaus, Reardon David A, Lee Eudocia Q, Rinne Mikael L, Norden Andrew D, Nayak Lakshmi, Ruland Sandra, Doherty Lisa M, LaFrankie Debra C, Horvath Margaret, Aizer Ayal A, Russo Andrea, Arvold Nils D, Claus Elizabeth B, Al-Mefty Ossama, Johnson Mark D, Golby Alexandra J, Dunn Ian F, Chiocca E Antonio, Trippa Lorenzo, Santagata Sandro, Folkerth Rebecca D, Kantoff Philip, Rollins Barrett J, Lindeman Neal I, Wen Patrick Y, Ligon Azra H, Beroukhim Rameen, Alexander Brian M, Ligon Keith L

Abstract excerpt

BACKGROUND: Multidimensional genotyping of formalin-fixed paraffin-embedded (FFPE) samples has the potential to improve diagnostics and clinical trials for brain tumors, but prospective use in the clinical setting is not yet routine. We report our experience with implementing a multiplexed copy n...

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Identifiers

PMID: 25754088
DOI: 10.1093/neuonc/nov015
PMCID: PMC4578577

Genes

PTEN
EGFR
IDH1
MET
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25754088-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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