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Article

Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies.

Oncotarget - 19 Apr 2016

Xiu Joanne, Piccioni David, Juarez Tiffany, Pingle Sandeep C, Hu Jethro, Rudnick Jeremy, Fink Karen, Spetzler David B, Maney Todd, Ghazalpour Anatole, Bender Ryan, Gatalica Zoran, Reddy Sandeep, Sanai Nader, Idbaih Ahmed, Glantz Michael, Kesari Santosh

Abstract excerpt

Glioblastomas (GBM) are the most aggressive and prevalent form of gliomas with abysmal prognosis and limited treatment options. We analyzed clinically relevant molecular aberrations suggestive of response to therapies in 1035 GBM tumors. Our analysis revealed mutations in 39 genes of 48 tested. IHC revealed expression of PD-L1 in 19% and PD-1 in 46%. MGMT-methylation was seen in 43%, EGFRvIII in 19% and 1p19q...

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Source

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Identifiers

PMID: 26933808
DOI: 10.18632/oncotarget.7722
PMCID: PMC5008305

Genes

MGMT
EGFR
IDH1

Provenance

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