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Article

Congenital Cataract in Gpr161vl/vl Mice Is Modified by Proximal Chromosome 15.

PloS one - 1 Jan 2017

Li Bo I, Ababon Myka R, Matteson Paul G, Lin Yong, Nanda Vikas, Millonig James H

Abstract excerpt

The morphology and severity of human congenital cataract varies even among individuals with the same mutation, suggesting that genetic background modifies phenotypic penetrance. The spontaneous mouse mutant, vacuolated lens (vl), arose on the C3H/HeSnJ background. The mutation disrupts secondary lens fiber development by E16.5, leading to full penetrance of congenital cataract. The vl locus was mapped to a...

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Share to Base Pairing
Share to Cataract
Share to Chromosomes, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to Lens, Crystalline

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Share to Receptors, G-Protein-Coupled

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Identifiers

PMID: 28135291
DOI: 10.1371/journal.pone.0170724
PMCID: PMC5279759

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