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Article

p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration.

Immunology and cell biology - 1 Sept 2015

Turvey Michelle E, Klingler-Hoffmann Manuela, Hoffmann Peter, McColl Shaun R

Abstract excerpt

Phosphoinositide 3-kinase γ (PI3Kγ) consists of the catalytic subunit p110γ that forms a mutually exclusive heterodimer with one of the two adaptor subunits, p101 or p84. Although activation of PI3Kγ is necessary for cell migration downstream of G-protein-coupled receptor engagement, particularly within the immune system, aberrant PI3Kγ signalling has been associated with transformation, increased migration and...

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PMID: 25753393
DOI: 10.1038/icb.2015.35

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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