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Article

p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis.

Blood - 26 Apr 2012

Krishnan Subha, Mali Raghuveer Singh, Ramdas Baskar, Sims Emily, Ma Peilin, Ghosh Joydeep, Munugalavadla Veerendra, Hanneman Philip, Beane Joal D, Kapur Reuben

Abstract excerpt

We show that loss of p85α inhibits the growth and maturation of mast cells, whereas loss of p85β enhances this process. Whereas restoring the expression of p85α in P85α(-/-) cells restores these functions, overexpression of p85β has the opposite effect. Consistently, overexpression of p85β in WT mast cells represses KIT-induced proliferation and IL-3-mediated maturation by inhibiting the expression of...

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Share to Class Ia Phosphatidylinositol 3-Kinase
Share to Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia

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Source

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Identifiers

PMID: 22378847
DOI: 10.1182/blood-2011-05-355602
PMCID: PMC3350362

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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