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Article

Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo.

The EMBO journal - 1 Mar 1999

Vanhaesebroeck B, Higashi K, Raven C, Welham M, Anderson S, Brennan P, Ward S G, Waterfield M D

Abstract excerpt

Phosphoinositide 3-kinases (PI3Ks) are lipid kinases which also possess an in vitro protein kinase activity towards themselves or their adaptor proteins. The physiological relevance of these phosphorylations is unclear at present. Here, the protein kinase activity of the tyrosine kinase-linked PI3K, p110delta, is characterized and its functional impact assessed. In vitro autophosphorylation of p110delta...

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Identifiers

PMID: 10064595
DOI: 10.1093/emboj/18.5.1292
PMCID: PMC1171219

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