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Article

A complicated case of atypical hemolytic uremic syndrome with frequent relapses under eculizumab.

Pediatric nephrology (Berlin, Germany) - 1 Jun 2015

Schalk Gesa, Kirschfink Michael, Wehling Cyrill, Gastoldi Sara, Bergmann Carsten, Hoppe Bernd, Weber Lutz T

Abstract excerpt

BACKGROUND: Atypical hemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy characterized by uncontrolled activation of the alternative complement pathway with consecutive generation of the terminal complement complex. Mortality is increased, particularly in the first year of the disease. Therapeutic options include plasma therapy and terminal complement blockade using the anti-C5 monoclonal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25752761
DOI: 10.1007/s00467-015-3078-6

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