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Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future

10 Jan 2021

Abstract excerpt

Chronic myeloid leukemia (CML) has been a "model disease" with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing on molecular pathways relating to signaling, metabolism and the bone marrow microenvironment. We...

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PMID: 33435150
DOI: 10.3390/cells10010117

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