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Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities

1 Mar 2019

Abstract excerpt

Abstract: Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of hematopoietic stem cells. At the molecular level, the disorder results from t(9;22)(q34;q11) reciprocal translocation between chromosomes, which leads to the formation of an oncogenic BCR–ABL gene fusion. Instead of progress in the understanding of the molecular etiology of CML and the development of novel therapeutic strategies,...

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PMID: 30880916
DOI: 10.2147/dddt.s191303

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