Article
Genetic variations of IL-28B and PD-1 are in association with the susceptibility and outcomes of HCV infection in Southeast China.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jun 2015
Xiao Wen, Zhang Qi, Deng Xiao Zhao, Jiang Long Feng, Zhu Dan Yan, Pei Jia Ping, Xu Mao Lei, Li Bing Jun, Wang Chang Jun, Zhang Jing Hai, Zhou Zhen Xian, Ding Wei Liang, Xu Xiao Dong, Yue Ming
Abstract excerpt
Programmed cell death-1 (PD-1) is an important co-inhibitory molecule involved in the progression of chronic viral infections. To investigate the associations of three single nucleotide polymorphisms (SNPs) (rs10204525, rs2227982 and rs36084323) in PD-1 and a previously well-inquired SNP rs12979860 in IL-28B with the outcomes of hepatitis C virus (HCV) infection in Southeast China, a total of 375 healthy...