Article
Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins.
The EMBO journal - 1 Jun 1992
Theill L E, Hattori K, Lazzaro D, Castrillo J L, Karin M
Abstract excerpt
The POU domain protein GHF-1 has a critical role in generation, proliferation and phenotypic expression of three pituitary cell types. GHF-1 functions in part by binding to and transactivating the promoters of both the growth hormone (GH) and prolactin (PRL) genes and that of the GHF1 gene itself. We describe a naturally occurring isoform of GHF-1, GHF-2, in which an additional 26 amino acids are inserted into...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- DNA-Binding Proteins
- Fetus
- Gene Library
- Genes
- Growth Hormone
- Introns
- Molecular Sequence Data
- Oligodeoxyribonucleotides