Overlapping Pit-1 and Sp1 binding sites are both essential to full rat growth hormone gene promoter activity despite mutually exclusive Pit-1 and Sp1 binding.

Article

Overlapping Pit-1 and Sp1 binding sites are both essential to full rat growth hormone gene promoter activity despite mutually exclusive Pit-1 and Sp1 binding.

The Journal of biological chemistry - 5 Oct 1990

Schaufele F, West B L, Reudelhuber T L

Abstract excerpt

A DNA-binding factor present in a wide variety of cell types is shown to bind to a site (GHF2) within the rat growth hormone gene promoter between nucleotides -147 and -129. Biochemical and transcriptional properties identify this factor as Sp1. The degree of glycosylation of one of the forms of...

Topics

Animals
Base Sequence
Binding Sites
Cell Line
Genes
Growth Hormone
Molecular Sequence Data
Mutation
Promoter Regions, Genetic
Rats
Sp1 Transcription Factor

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