Article
Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression.
Genes & development - 1 Sept 1993
Lipkin S M, Näär A M, Kalla K A, Sack R A, Rosenfeld M G
Abstract excerpt
The growth hormone (GH) and prolactin genes require the pituitary-specific POU domain transcription factor Pit-1 for their activation. However, additional factors are necessary for the effective expression of these genes. Analysis of evolutionarily conserved sequences in the proximal GH promoter...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Evolution
- Cell Line
- Cloning, Molecular
- Conserved Sequence
- DNA
- DNA-Binding Proteins
- Growth Hormone
- Humans
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Multigene Family
- Mutation
- Promoter Regions, Genetic
- Rats