Specification of unique Pit-1 activity in the hGH locus control region

doi:10.1073/pnas.182418199

Article

Specification of unique Pit-1 activity in the hGH locus control region

20 Aug 2002

Abstract excerpt

The human GH (hGH) gene cluster is regulated by a remote 5' locus control region (LCR). HSI, an LCR component located 14.5 kb 5' to the hGH-N promoter, constitutes the primary determinant of high-level hGH-N activation in pituitary somatotropes. HSI encompasses an array of three binding sites for the pituitary-specific POU homeodomain factor Pit-1. In the present report we demonstrate that all three Pit-1 sites...

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