Article
TGFβ1 genetic variants are associated with an increased risk of acute brucellosis.
Infectious diseases (London, England) - 1 Jul 2015
Sepanjnia Adel, Eskandari-Nasab Ebrahim, Moghadampour Mehdi, Tahmasebi Arezoo, Dahmardeh Fatemeh
Abstract excerpt
OBJECTIVE: Cytokines play a critical role in the regulation of the immune response against brucellosis infection, and mediate production of many pro- and anti-inflammatory signals. Transforming growth factor-beta 1 (TGFβ1), a powerful suppressive cytokine, inhibits macrophage activation and modulates T-cell function, and plays crucial roles in regulation of microbial replication and host responses to brucella....
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