Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MCM2 is a therapeutic target of lovastatin in human non-small cell lung carcinomas

27 Feb 2015

Abstract excerpt

Human non-small cell lung carcinoma (NSCLC) is one of the most common cancer worldwide. In previous studies, lovastatin, acting as an inhibitor of 3-hydroxy-3-methylglutaryl Co A (HMG-CoA) reductase, exhibited significant antitumor activity during tumorigenesis. However, whether or not this effect is mediated through changes in minichromosome maintenance (MCM) 2 expression remains unclear. The present study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer, Lipids, and Metabolism
Share to Ferroptosis and cancer prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25738322
DOI: 10.3892/or.2015.3822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MCM2 is a therapeutic target of lovastatin in human non-small cell lung carcinomasPMID 25738322Read ↗

Potential Prospective Biomarkers for Non-small Cell Lung Cancer: Mini-Chromosome Maintenance ProteinsSemantic proximity Read ↗

Transcription factor E2F1 promotes non-small cell lung cancer progression by activating the PI3K/AKT pathway through MCM4Semantic proximity Read ↗

Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer.Semantic proximity Read ↗

Induction of Cell Cycle Arrest, Apoptosis, and Reducing the Expression of MCM Proteins in Human Lung Carcinoma A549 Cells by Cedrol, Isolated fromJuniperus chinensisSemantic proximity Read ↗

MCM2 in human cancer: functions, mechanisms, and clinical significanceSemantic proximity Read ↗

Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations.Semantic proximity Read ↗

Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism.Semantic proximity Read ↗

Lovastatin Induces Growth Inhibition and Apoptosis in Human Malignant Glioma CellsSemantic proximity Read ↗

Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis.Semantic proximity Read ↗

Therapeutic effects of statins against lung adenocarcinoma via p53 mutant-mediated apoptosisSemantic proximity Read ↗

Lovastatin induces apoptosis through the mitochondrial pathway in an undifferentiated SH-SY5Y neuroblastoma cell lineSemantic proximity Read ↗

Mevastatin can cause G1 arrest and induce apoptosis in pulmonary artery smooth muscle cells through a p27Kip1-independent pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.