Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Therapeutic effects of statins against lung adenocarcinoma via p53 mutant-mediated apoptosis

31 Dec 2019

Abstract excerpt

The p53 gene is an important tumour suppressor gene. Mutant p53 genes account for about half of all lung cancer cases. There is increasing evidence for the anti-tumour effects of statins via inhibition of the mevalonate pathway. We retrospectively investigated the correlation between statin use and lung cancer prognosis using the Taiwanese National Health Insurance Research Database, mainly focusing on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Lipids, and Metabolism
Share to Cancer-related Molecular Pathways
Share to Ferroptosis and cancer prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31892709
DOI: 10.1038/s41598-019-56532-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Therapeutic effects of statins against lung adenocarcinoma via p53 mutant-mediated apoptosisPMID 31892709Read ↗

Statin improves survival in patients with EGFR-TKI lung cancer: A nationwide population-based study.Semantic proximity Read ↗

Targeting Apoptotic Signaling Pathways in Human Lung CancerSemantic proximity Read ↗

Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity.Semantic proximity Read ↗

The role of statins as therapeutic agents in cancerSemantic proximity Read ↗

MiR-4458 Regulates Autophagy and Apoptosis By Targeting P53 In Chronic Obstructive Pulmonary Disease.Semantic proximity Read ↗

Nanoparticles targeting mutant p53 overcome chemoresistance and tumor recurrence in non-small cell lung cancer.Semantic proximity Read ↗

PAQR3 Inhibits Non-small Cell Lung Cancer Growth by Regulating the NF-κB/p53/Bax AxisSemantic proximity Read ↗

Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis.Semantic proximity Read ↗

4-FPAC-Modulated Tumor-Associated Macrophage Conditioned Media Suppresses Malignant Phenotypes and Promotes Cell-Cycle Arrest and Apoptosis in NSCLC.Semantic proximity Read ↗

Atorvastatin overcomes gefitinib resistance in KRAS mutant human non-small cell lung carcinoma cells.Semantic proximity Read ↗

MiR-144 Inhibits Proliferation and Induces Apoptosis and Autophagy in Lung Cancer Cells by Targeting TIGARSemantic proximity Read ↗

Statins augment efficacy of EGFR-TKIs in patients with advanced-stage non-small cell lung cancer harbouring KRAS mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.