Article
Mutation testing for directing upfront targeted therapy and post-progression combination therapy strategies in lung adenocarcinoma.
Expert review of molecular diagnostics - 1 Jul 2016
Salgia Ravi
Abstract excerpt
INTRODUCTION: Advances in the biology of non-small-cell lung cancer, especially adenocarcinoma, reveal multiple molecular subtypes driving oncogenesis. Accordingly, individualized targeted therapeutics are based on mutational diagnostics. AREAS COVERED: Advances in strategies and techniques for individualized treatment, particularly of adenocarcinoma, are described through literature review. Approved therapies...
Topics
- Carcinoma, Non-Small-Cell Lung
- DNA, Neoplasm
- Drug Therapy, Combination
- Genetic Testing
- Humans
- Lung Neoplasms
- Mutation
- Sequence Analysis, DNA