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Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice

3 Nov 2021

Abstract excerpt

Endochondral ossification is regulated by transcription factors that include SRY-box transcription factor 9, runt-related protein 2 (Runx2), and Osterix. However, the sequential and harmonious regulation of the multiple steps of endochondral ossification is unclear. This study identified zinc finger homeodomain 4 (Zfhx4) as a crucial transcriptional partner of Osterix. We found that Zfhx4 was highly expressed in...

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PMID: 34732852
DOI: 10.1038/s42003-021-02793-9

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