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Article

Histone H3K27 demethylase, Utx, regulates osteoblast-to-osteocyte differentiation.

Biochemical and biophysical research communications - 29 Jan 2022

Xia Yuhan, Ikedo Aoi, Lee Ji-Won, Iimura Tadahiro, Inoue Kazuki, Imai Yuuki

Abstract excerpt

Osteocytes are master regulators of skeletal homeostasis. However, little is known about the molecular mechanism of their differentiation. Epigenetic regulations, especially H3K27me3 modification, play critical roles in cell differentiation. Here, we found that H3K27me3 in the loci of osteocyte-expressing genes decreased during osteocyte differentiation and that H3K27me3 demethylase, Utx, was bound to the loci of...

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PMID: 34974301
DOI: 10.1016/j.bbrc.2021.12.102

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