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Article

Association of the eNOS E298D polymorphism and the risk of myocardial infarction in the Greek population.

BMC medical genetics - 20 Sept 2010

Dafni Chaido, Drakoulis Nikolaos, Landt Olfert, Panidis Dimitris, Reczko Martin, Cokkinos Dennis V

Abstract excerpt

BACKGROUND: Nitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS), plays a key role in the regulation of vascular tone. Endothelium-derived NO exerts vasoprotective effects by suppressing platelet aggregation, leukocyte adhesion and smooth muscle cell proliferation. The E298D polymorphic variant of eNOS has been associated with myocardial infarction (MI), but data relating to this variant are...

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PMID: 20854685
DOI: 10.1186/1471-2350-11-133
PMCID: PMC2954842

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