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Gene-gene interaction and RNA splicing profiles of MAP2K4 gene in rheumatoid arthritis.

Clinical immunology (Orlando, Fla.) - 1 May 2015

Shchetynsky Klementy, Protsyuk Darya, Ronninger Marcus, Diaz-Gallo Lina-Marcela, Klareskog Lars, Padyukov Leonid

Abstract excerpt

We performed gene-gene interaction analysis, with HLA-DRB1 shared epitope (SE) alleles for 195 SNPs within immunologically important MAP2K, MAP3K and MAP4K gene families, in 2010 rheumatoid arthritis (RA) patients and 2280 healthy controls. We found a significant statistical interaction for rs10468473 with SE alleles in autoantibody-positive RA. Individuals heterozygous for rs10468473 demonstrated higher...

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PMID: 25732927
DOI: 10.1016/j.clim.2015.02.011

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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