Article
Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle.
Scientific reports - 3 Mar 2015
Gouspillou Gilles, Scheede-Bergdahl Celena, Spendiff Sally, Vuda Madhusudanarao, Meehan Brian, Mlynarski Heather, Archer-Lahlou Elodie, Sgarioto Nicolas, Purves-Smith Fennigje M, Konokhova Yana, Rak Janusz, Chevalier Stéphanie, Taivassalo Tanja, Hepple Russell T, Jagoe R Thomas
Abstract excerpt
Anticancer treatments for childhood acute lymphoblastic leukaemia (ALL) are highly effective but are now implicated in causing impaired muscle function in long-term survivors. However, no comprehensive assessment of skeletal muscle mitochondrial functions in long-term survivors has been performed and the presence of persistent chemotherapy-induced skeletal muscle mitochondrial dysfunction remains a strong...
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