Article

Doxorubicin-Induced p53 Interferes with Mitophagy in Cardiac Fibroblasts

2019-06-17

Abstract excerpt

Doxorubicin is a mainstay in pediatric chemotherapy treatment because of its efficacy treating leukemia and lymphoma. Unfortunately, every childhood cancer survivor will develop a chronic health problem, one of the most serious being cardiac disease. How doxorubicin damages the heart in such a way that disease progression occurs over multiple decades is still not understood. The dose of doxorubicin selected does n...

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Literature Corpus work: 19f08e2b-e226-5a47-97b6-53e1712d8362
DOI: 10.1101/674309

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