Article
Cooperative genetic changes in pediatric B-cell precursor acute lymphoblastic leukemia with deletions or mutations of IKZF1.
Genes, chromosomes & cancer - 1 May 2015
Olsson Linda, Albitar Ferras, Castor Anders, Behrendtz Mikael, Biloglav Andrea, Paulsson Kajsa, Johansson Bertil
Abstract excerpt
In contrast to IKZF1 deletions (ΔIKZF1), IKZF1 sequence mutations (mutIKZF1) have been reported to be rare in B-cell precursor acute lymphoblastic leukemia and their clinical implications are unknown. We performed targeted deep sequencing of all exons of IKZF1 in 140 pediatric cases, eight (5.7%) of which harbored a mutIKZF1. The probabilities of relapse (pRel) and event-free survival (pEFS) did not differ...
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